Clonidine, dexmedetomidine: alpha-2 adrenergic receptor agonists in neuroscience
نویسندگان
چکیده
منابع مشابه
alpha2-Adrenergic agonists protect against radiocontrast-induced nephropathy in mice.
Radiocontrast nephropathy (RCN) is a common clinical problem for which there is no effective therapy. Utilizing a murine model, we tested the hypothesis that alpha(2)-adrenergic receptor agonists (clonidine and dexmedetomidine) protect against RCN induced with iohexol (a nonionic low-osmolar radiocontrast). C57BL/6 mice were pretreated with saline, clonidine, or dexmedetomidine before induction...
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Interruption of long-term treatment with alpha 2-adrenergic receptor agonists may be associated with reversal of their hemodynamic effects, clinical and biochemical evidence of increased peripheral sympathetic activity, and behavioral responses similar to those seen after narcotic or alcohol withdrawal. Reactions are most commonly observed after short-acting imidazoline drugs such as clonidine ...
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PURPOSE The glaucomas are characterized by chronic progressive ganglion cell loss over many years. A drug with neuroprotective activity should increase the resistance of retinal ganglion cells (RGC) to chronic stress or injury and therefore enhance survival. Brimonidine is a highly selective and potent alpha-2 adrenergic receptor agonist, which lowers intra-ocu-lar pressure (IOP) and is neuropr...
متن کاملSelective 2-adrenergic properties of dexmedetomidine over clonidine in the human forearm
Masuki, Shizue, Frank A. Dinenno, Michael J. Joyner, and John H. Eisenach. Selective 2-adrenergic properties of dexmedetomidine over clonidine in the human forearm. J Appl Physiol 99: 587–592, 2005. First published March 31, 2005; doi:10.1152/japplphysiol.00147.2005.— We tested the hypothesis that dexmedetomidine (Dex) has greater 2vs. 1 selectivity than clonidine and causes more 2-selective va...
متن کاملInhaled beta-2 adrenergic receptor agonists and primary cardiac arrest.
PURPOSE We sought to investigate if short-acting, inhaled beta2-adrenergic receptor agonists were associated with higher risk of primary cardiac arrest in patients with asthma or chronic obstructive pulmonary disease (COPD). SUBJECTS AND METHODS We conducted a population-based study involving 454 patients enrolled in a health maintenance organization, aged 40 to 79 years, who had asthma or CO...
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ژورنال
عنوان ژورنال: International Journal of Basic & Clinical Pharmacology
سال: 2018
ISSN: 2279-0780,2319-2003
DOI: 10.18203/2319-2003.ijbcp20184870